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Search the School of Mathematical SciencesPeople matching "+Fluid +mechanics"Courses matching "+Fluid +mechanics" 
Fluid Mechanics III Fluid flows are important in many scientific and technological problems including atmospheric and oceanic circulation, energy production by chemical or nuclear combustion in engines and stars, energy utilisation in vehicles, buildings and industrial processes, and biological processes such as the flow of blood.
Considerable progress has been made in the mathematical modelling of fluid flows and this has greatly improved our understanding of these problems, but there is still much to discover. This course introduces students to the mathematical description of fluid flows and the solution of some important flow problems.
Topics covered are: the mathematical description of fluid flow in terms of Lagrangian and Eulerian coordinates; the derivation of the Euler, NavierStokes and Bernoulli equations from the fundamental physical principles of mass and momentum conservation; use of the stream function, velocity potential and complex potential are introduced to find solutions of the governing equations for inviscid, irrotational flow past bodies and the forces acting on those bodies; solutions of the NavierStokes equations for simple viscous flows.
More about this course... 
Events matching "+Fluid +mechanics" 
The Mechanics of Nanoscale Devices 15:10 Fri 10 Oct, 2008 :: G03 Napier Building University of Adelaide :: Associate Prof. John Sader :: Department of Mathematics and Statistics, The University of Melbourne
Nanomechanical sensors are often used to measure environmental
changes with extreme sensitivity. Controlling the effects of surfaces and
fluid dissipation presents significant challenges to achieving the
ultimate sensitivity in these devices. In this talk, I will give an
overview of theoretical/experimental work we are undertaking to explore
the underlying physical processes in these systems. The talk will be
general and aimed at introducing some recent developments in the field of
nanomechanical sensors. 

Big whirls 15:00 Fri 30 Jan, 2009 :: School Board Room :: A/Prof Richard Kelso :: University of Adelaide


Impulsively generated drops 15:00 Fri 27 Feb, 2009 :: Napier LG29 :: Prof William Phillips :: Swinburne University of Technology
This talk is concerned with the evolution of an unbounded inviscid fluidfluid
interface subject to an axisymmetric impulse in pressure and how inertial,
interfacial and gravitational forces affect that evolution. The construct was
motivated by the occurrence of lung hemorrhage resulting from ultrasonic
imaging and pursues the notion that bursts of ultrasound act to expel droplets
that puncture the soft airfilled sacs in the lung plural surface allowing them
to fill with blood. The evolution of the free surface is described by a
boundary integral formulation which is integrated forward in time numerically.
As the interface evolves, it is seen, depending upon the levels of gravity and
surface tension, to form either axisymmetric surface jets, waves or droplets.
Moreover the droplets may be spherical, inverted tearshaped or pancake like.
Also of interest is the finite time singularity which occurs when the drop
pinches off; this is seen to be of the power law type with an exponent of 2/3.


Understanding optimal linear transient growth in complexgeometry flows 15:00 Fri 27 Mar, 2009 :: Napier LG29 :: Associate Prof Hugh Blackburn :: Monash University


Sloshing in tanks of liquefied natural gas (LNG) vessels 15:10 Wed 22 Apr, 2009 :: Napier LG29 :: Prof. Frederic Dias :: ENS, Cachan
The last scientific conversation I had with Ernie Tuck was on liquid impact. As a matter of fact, we discussed the paper by J.H. Milgram, Journal of Fluid Mechanics 37 (1969), entitled "The motion of a fluid in a cylindrical container with a free surface following vertical impact."
Liquid impact is a key issue in sloshing and in particular in sloshing in tanks of LNG vessels. Numerical simulations of sloshing have been performed by various groups, using various types of numerical methods. In terms of the numerical results, the outcome is often impressive, but the question remains of how relevant these results are when it comes to determining impact pressures. The numerical models are too simplified to reproduce the high variability of the measured pressures. In fact, for the time being, it is not possible to simulate accurately both global and local effects. Unfortunately it appears that local effects predominate over global effects when the behaviour of pressures is considered.
Having said this, it is important to point out that numerical studies can be quite useful to perform sensitivity analyses in idealized conditions such as a liquid mass falling under gravity on top of a horizontal wall and then spreading along the lateral sides. Simple analytical models inspired by numerical results on idealized problems can also be useful to predict trends.
The talk is organized as follows: After a brief introduction on the sloshing problem and on scaling laws, it will be explained to what extent numerical studies can be used to improve our understanding of impact pressures. Results on a liquid mass hitting a wall obtained by a finitevolume code with interface reconstruction as well as results obtained by a simple analytical model will be shown to reproduce the trends of experiments on sloshing.
This is joint work with L. Brosset (GazTransport & Technigaz), J.M. Ghidaglia (ENS Cachan) and J.P. Braeunig (INRIA). 

Magnetorotational instabilities in cylindrical TaylorCouette flow 15:00 Fri 24 Apr, 2009 :: Napier LG29 :: Dr Rainer Hollerbach :: University of Leeds


Wall turbulence: from the laboratory to the atmosphere 15:00 Fri 29 May, 2009 :: Napier LG29 :: Prof Ivan Marusic :: The University of Melbourne
The study of wallbounded turbulent flows has received great attention over
the past few years as a result of high Reynolds number experiments conducted
in new high Reynolds number facilities such as the Princeton "superpipe",
the NDF facility in Chicago and the HRNBLWT at the University of Melbourne.
These experiments have brought into question the fundamental scaling laws of
the turbulence and mean flow quantities as well as revealed high Reynolds
number phenomena, which make extrapolation of low Reynolds number
results highly questionable.
In this talk these issues will be reviewed and new results from the HRNBLWT
and atmospheric surface layer on the saltflats of Utah will be presented
documenting unique high Reynolds number phenomena. The implications for
skinfriction drag reduction technologies and improved nearwall models for
largeeddy simulation will be discussed. 

Nonlinear diffusiondriven flow in a stratified viscous fluid 15:00 Fri 26 Jun, 2009 :: Macbeth Lecture Theatre :: Associate Prof Michael Page :: Monash University
In 1970, two independent studies (by Wunsch and Phillips) of the behaviour of a linear densitystratified viscous fluid in a closed container demonstrated a slow flow can be generated simply due to the container having a sloping boundary surface This remarkable motion is generated as a result of the curvature of the lines of constant density near any sloping surface, which in turn enables a zero normalflux condition on the density to be satisfied along that boundary. When the Rayleigh number is large (or equivalently Wunsch's parameter $R$ is small) this motion is concentrated in the near vicinity of the sloping surface, in a thin `buoyancy layer' that has many similarities to an Ekman layer in a rotating fluid.
A number of studies have since considered the consequences of this type of `diffusivelydriven' flow in a semiinfinite domain, including in the deep ocean and with turbulent effects included. More recently, Page & Johnson (2008) described a steady linear theory for the broaderscale mass recirculation in a closed container and demonstrated that, unlike in previous studies, it is possible for the buoyancy layer to entrain fluid from that recirculation. That work has since been extended (Page & Johnson, 2009) to the nonlinear regime of the problem and some of the similarities to and differences from the linear case will be described in this talk. Simple and elegant analytical solutions in the limit as $R \to 0$ still exist in some situations, and they will be compared with numerical simulations in a tilted square container at small values of $R$. Further work on both the unsteady flow properties and the flow for other geometrical configurations will also be described. 

Modelling fluidstructure interactions in microdevices 15:00 Thu 3 Sep, 2009 :: School Board Room :: Dr Richard Clarke :: University of Auckland
The flows generated in many modern microdevices possess very little convective inertia, however, they can be highly unsteady and exert substantial hydrodynamic forces on the device components. Typically these components exhibit some degree of compliance, which traditionally has been treated using simple onedimensional elastic beam models. However, recent findings have suggested that threedimensional effects can be important and, accordingly, we consider the elastohydrodynamic response of a rapidly oscillating threedimensional elastic plate that is immersed in a viscous fluid. In addition, a preliminary model will be presented which incorporates the presence of a nearby elastic wall. 

Spinup in a torus 16:00 Thu 3 Sep, 2009 :: School Board Room :: Dr Richard Hewitt :: University of Manchester


Stability of rotating boundarylayers 15:10 Wed 16 Sep, 2009 :: Napier LG29 :: Dr Christian Thomas :: University of Western Australia


Eigenanalysis of fluidloaded compliant panels 15:10 Wed 9 Dec, 2009 :: Santos Lecture Theatre :: Prof Tony Lucey :: Curtin University of Technology
This presentation concerns the fluidstructure interaction (FSI) that occurs between a fluid flow and an arbitrarily deforming flexible boundary considered to be a flexible panel or a compliant coating that comprises the wetted surface of a marine vehicle. We develop and deploy an approach that is a hybrid of computational and theoretical techniques. The system studied is twodimensional and linearised disturbances are assumed. Of particular novelty in the present work is the ability of our methods to extract a full set of fluidstructure eigenmodes for systems that have strong spatial inhomogeneity in the structure of the flexible wall.
We first present the approach and some results of the system in which an ideal, zeropressure gradient, flow interacts with a flexible plate held at both its ends. We use a combination of boundaryelement and finitedifference methods to express the FSI system as a single matrix equation in the interfacial variable. This is then couched in statespace form and standard methods used to extract the system eigenvalues. It is then shown how the incorporation of spatial inhomogeneity in the stiffness of the plate can be either stabilising or destabilising. We also show that adding a further restraint within the streamwise extent of a homogeneous panel can trigger an additional type of hydroelastic instability at low flow speeds. The mechanism for the fluidtostructure energy transfer that underpins this instability can be explained in terms of the pressuresignal phase relative to that of the wall motion and the effect on this relationship of the added wall restraint.
We then show how the idealflow approach can be conceptually extended to include boundarylayer effects. The flow field is now modelled by the continuity equation and the linearised perturbation momentum equation written in velocityvelocity form. The nearwall flow field is spatially discretised into rectangular elements on an Eulerian grid and a variant of the discretevortex method is applied. The entire fluidstructure system can again be assembled as a linear system for a single set of unknowns  the flowfield vorticity and the wall displacements  that admits the extraction of eigenvalues. We then show how stability diagrams for the fullycoupled finite flowstructure system can be assembled, in doing so identifying classes of wallbased or fluidbased and spatiotemporal wave behaviour.


The Jeffery–Hamel similarity solution and its relation to flow in a diverging channel 15:10 Fri 19 Mar, 2010 :: Santos Lecture Theatre :: Dr Phil Haines :: University of Adelaide
Jeffery–Hamel flows describe the steady twodimensional flow of an
incompressible viscous fluid between plane walls separated by an angle
$\alpha$. They are often used to approximate the flow in domains of finite
radial extent. However, whilst the base Jeffery–Hamel solution is
characterised by a subcritical pitchfork bifurcation, studies in expanding
channels of finite length typically find symmetry breaking via a supercritical
bifurcation.
We use the finite element method to calculate solutions for flow in a
twodimensional wedge of finite length bounded by arcs of constant radii, $R_1$
and $R_2$. We present a comprehensive picture of the bifurcation structure and
nonlinear states for a net radial outflow of fluid. We find a series of nested
neutral curves in the Reynolds number$\alpha$ plane
corresponding to pitchfork bifurcations that break the midplane symmetry of the
flow. We show that these finite domain bifurcations remain distinct from the
similarity solution bifurcation even in the limit $R_2/R_1 \rightarrow \infty$.
We also discuss a class of stable steady solutions apparently related to a
steady, spatially periodic, wave first observed by Tutty (1996). These
solutions remain disconnected in our domain in the sense that they do not
arise via a local bifurcation of the Stokes flow solution as the Reynolds
number is increased. 

The fluid mechanics of gels used in tissue engineering 15:10 Fri 9 Apr, 2010 :: Santos Lecture Theatre :: Dr Edward Green :: University of Western Australia
Tissue engineering could be called 'the science of spare parts'.
Although currently in its infancy, its longterm aim is to grow
functional tissues and organs in vitro to replace those which have
become defective through age, trauma or disease. Recent experiments
have shown that mechanical interactions between cells and the materials
in which they are grown have an important influence on tissue
architecture, but in order to understand these effects, we first need to
understand the mechanics of the gels themselves.
Many biological gels (e.g. collagen) used in tissue engineering have a
fibrous microstructure which affects the way forces are transmitted
through the material, and which in turn affects cell migration and other
behaviours. I will present a simple continuum model of gel mechanics,
based on treating the gel as a transversely isotropic viscous material.
Two canonical problems are considered involving thin twodimensional
films: extensional flow, and squeezing flow of the fluid between two
rigid plates. Neglecting inertia, gravity and surface tension, in each
regime we can exploit the thin geometry to obtain a leadingorder
problem which is sufficiently tractable to allow the use of analytical
methods. I discuss how these results could be exploited practically to
determine the mechanical properties of real gels. If time permits, I
will also talk about work currently in progress which explores the
interaction between gel mechanics and cell behaviour. 

Two problems in porous media flow 15:10 Tue 11 May, 2010 :: Santos Lecture Theatre :: A/Prof Graeme Hocking :: Murdoch University
I will discuss two problems in porous media flow.
On a tropical island, fresh water may sit in the soil beneath the
ground, floating on the ocean's salt water. This water is a valuable
resource for the inhabitants, but requires sufficient rainfall to
recharge the lens. In this paper, Green's functions are used to derive
an integral equation to satisfy all of the conditions except those on
the interfaces, which are then solved for numerically. Conditions under
which the lens can be maintained will be described. This is work I did
with an Honours student, Sue Chen, who is now at U. Melbourne.
In the second problem, I will discuss an "exact" solution to a problem
in withdrawal from an unconfined aquifer. The problem formulation gives
rise to a singular integral equation that can be solved using a nice
orthogonality result I first met in airfoil theory. This is work with
Hong Zhang from Griffith University. 

Understanding convergence of meshless methods: Vortex methods and smoothed particle hydrodynamics 15:10 Fri 14 May, 2010 :: Santos Lecture Theatre :: A/Prof Lou Rossi :: University of Delaware
Meshless methods such as vortex methods (VMs) and smoothed particle
hydrodynamics (SPH) schemes offer many advantages in fluid flow computations.
Particlebased computations naturally adapt to complex flow geometries
and so provide a high degree of computational efficiency. Also, particle
based methods avoid CFL conditions because flow quantities are
integrated along characteristics. There are many approaches to
improving numerical methods, but one of the most effective routes
is quantifying the error through the direct estimate of residual
quantities. Understanding the residual for particle schemes requires
a different approach than for meshless schemes but the rewards are
significant. In this seminar, I will outline a general approach to
understanding convergence that has been effective in creating high
spatial accuracy vortex methods, and then I will discuss some recent
investigations in the accuracy of diffusion operators used in SPH
computations. Finally, I will provide some sample NavierStokes
computations of high Reynolds number flows using BlobFlow, an open
source implementation of the high precision vortex method. 

A variance constraining ensemble Kalman filter: how to improve forecast using climatic data of unobserved variables 15:10 Fri 28 May, 2010 :: Santos Lecture Theatre :: A/Prof Georg Gottwald :: The University of Sydney
Data assimilation aims to solve one of the fundamental problems ofnumerical weather prediction  estimating the optimal state of the
atmosphere given a numerical model of the dynamics, and sparse, noisy
observations of the system. A standard tool in attacking this
filtering problem is the Kalman filter.
We consider the problem when only partial observations are available.
In particular we consider the situation where the observational space
consists of variables which are directly observable with known
observational error, and of variables of which only their climatic
variance and mean are given. We derive the corresponding Kalman
filter in a variational setting.
We analyze the variance constraining Kalman filter (VCKF) filter for
a simple linear toy model and determine its range of optimal
performance. We explore the variance constraining Kalman filter in an
ensemble transform setting for the Lorenz96 system, and show that
incorporating the information on the variance on some unobservable
variables can improve the skill and also increase the stability of
the data assimilation procedure.
Using methods from dynamical systems theory we then systems where the
unobserved variables evolve deterministically but chaotically on a
fast time scale.
This is joint work with Lewis Mitchell and Sebastian Reich.


Topological chaos in two and three dimensions 15:10 Fri 18 Jun, 2010 :: Santos Lecture Theatre :: Dr Matt Finn :: School of Mathematical Sciences
Research into twodimensional laminar fluid mixing has enjoyed a
renaissance in the last decade since the realisation that the
Thurston–Nielsen theory of surface homeomorphisms can assist in
designing efficient "topologically chaotic" batch mixers.
In this talk I will survey some tools used in topological fluid
kinematics, including braid groups, traintracks, dynamical systems and
topological index formulae. I will then make some speculations about
topological chaos in three dimensions. 

Electrified film flow over topography 15:10 Mon 5 Jul, 2010 :: 5.58 Ingkarni Wardli :: Dr Mark Blyth :: University of East Anglia


Hugs not drugs 15:10 Mon 20 Sep, 2010 :: Ingkarni Wardli B17 :: Dr Scott McCue :: Queensland University of Technology
I will discuss a model for drug diffusion that involves a Stefan problem with a "kinetic undercooling". I like Stefan problems, so I like this model. I like drugs too, but only legal ones of course. Anyway, it turns out that in some parameter regimes, this sophisticated moving boundary problem hardly works better than a simple linear undergraduate model (there's a lesson here for mathematical modelling). On the other hand, for certain polymer capsules, the results are interesting and suggest new means for controlled drug delivery. If time permits, I may discuss certain asymptotic limits that are of interest from a Stefan problem perspective. Finally, I won't bring any drugs with me to the seminar, but I'm willing to provide hugs if necessary. 

The mathematics of smell 15:10 Wed 29 Sep, 2010 :: Ingkarni Wardli 5.57 :: Dr Michael Borgas :: CSIRO Light Metals Flagship; Marine and Atmospheric Research; Centre for Australian Weather and Clim
The sense of smell is important in nature, but the least well understood of our senses. A mathematical model of smell, which combines the transmission of volatileorganiccompound chemical signals (VOCs) on the wind, transduced by olfactory receptors in our noses into neural information, and assembled into our odour perception, is useful. Applications include regulations for odour nuisance, like German VDI protocols for calibrated noses, to the design of modern chemical sensors for extracting information from the environment and even for the perfume industry. This talk gives a broad overview of turbulent mixing in surface layers of the atmosphere, measurements of VOCs with PTRMS (proton transfer reaction mass spectrometers), our noses, and integrated environmental models of the Alumina industry (a source of odour emissions) to help understand the science of smell. 

Statistical physics and behavioral adaptation to Creation's main stimuli: sex and food 15:10 Fri 29 Oct, 2010 :: E10 B17 Suite 1 :: Prof Laurent Seuront :: Flinders University and South Australian Research and Development Institute
Animals typically search for food and mates, while avoiding predators. This is particularly critical for keystone organisms such as intertidal gastropods and copepods (i.e. millimeterscale crustaceans) as they typically rely on nonvisual senses for detecting, identifying and locating mates in their two and threedimensional environments. Here, using stochastic methods derived from the field of nonlinear physics, we provide new insights into the nature (i.e. innate vs. acquired) of the motion behavior of gastropods and copepods, and demonstrate how changes in their behavioral properties can be used to identify the tradeoffs between foraging for food or sex. The gastropod Littorina littorea hence moves according to fractional Brownian motions while foraging for food (in accordance with the fractal nature of food distributions), and switch to Brownian motion while foraging for sex. In contrast, the swimming behavior of the copepod Temora longicornis belongs to the class of multifractal random walks (MRW; i.e. a form of anomalous diffusion), characterized by a nonlinear moment scaling function for distance versus time. This clearly differs from the traditional Brownian and fractional Brownian walks expected or previously detected in animal behaviors. The divergence between MRW and Levy flight and walk is also discussed, and it is shown how copepod anomalous diffusion is enhanced by the presence and concentration of conspecific waterborne signals, and is dramatically increasing malefemale encounter rates. 

Heat transfer scaling and emergence of threedimensional flow in horizontal convection 15:10 Fri 25 Feb, 2011 :: Conference Room Level 7 Ingkarni Wardli :: Dr Greg Sheard :: Monash University
Horizontal convecton refers to flows driven by uneven heating on a horizontal forcing boundary. Flows exhibiting these characteristics are prevalent in nature, and include the NorthSouth Hadley circulation within the atmosphere between warmer and more temperate latitudes, as well as ocean currents driven by nonuniform heating via solar radiation.
Here a model for these generic convection flows is established featuring a rectangular enclosure, insulated on the side and top
walls, and driven by a linear temperature gradient applied along the bottom wall. Rayleigh number dependence of heat transfer
through the forcing boundary is computed and compared with theory. Attention is given to transitions in the flow, including the
development of unsteady flow and threedimensional flow: the effect of these transitions on the NusseltRayleigh number scaling exponents is described.


Heat transfer scaling and emergence of threedimensional flow in horizontal convection 15:10 Fri 25 Mar, 2011 :: Conference Room Level 7 Ingkarni Wardli :: Dr Greg Sheard :: Monash University


The Cauchy integral formula 12:10 Mon 9 May, 2011 :: 5.57 Ingkarni Wardli :: Stephen Wade :: University of Adelaide
In this talk I will explain a simple method used for calculating the Hilbert transform of an analytic function, and provide some assurance that this isn't a bad thing to do in spite of the somewhat ominous presence of infinite areas. As it turns out this type of integral is not without an application, as will be demonstrated by one application to a problem in fluid mechanics. 

Permeability of heterogeneous porous media  experiments, mathematics and computations 15:10 Fri 27 May, 2011 :: B.21 Ingkarni Wardli :: Prof Patrick Selvadurai :: Department of Civil Engineering and Applied Mechanics, McGill University
Permeability is a key parameter important to a variety of applications in geological engineering and in the environmental geosciences. The conventional definition of Darcy flow enables the estimation of permeability at different levels of detail. This lecture will focus on the measurement of surface permeability characteristics of a large cuboidal block of Indiana Limestone, using a surface permeameter. The paper discusses the theoretical developments, the solution of the resulting triple integral equations and associated computational treatments that enable the mapping of the near surface permeability of the cuboidal region. This data combined with a kriging procedure is used to develop results for the permeability distribution at the interior of the cuboidal region. Upon verification of the absence of dominant pathways for fluid flow through the cuboidal region, estimates are obtained for the "Effective Permeability" of the cuboid using estimates proposed by Wiener, Landau and Lifschitz, King, Matheron, Journel et al., Dagan and others. The results of these estimates are compared with the geometric mean, derived form the computational estimates. 

Boundaries of unsteady Lagrangian Coherent Structures 15:10 Wed 10 Aug, 2011 :: 5.57 Ingkarni Wardli :: Dr Sanjeeva Balasuriya :: Connecticut College, USA and the University of Adelaide
For steady flows, the boundaries of Lagrangian Coherent Structures
are segments of manifolds connected to fixed points. In the general
unsteady situation, these boundaries are timevarying manifolds of
hyperbolic trajectories. Locating these boundaries, and attempting
to meaningfully quantify fluid flux across them, is difficult since they
are moving with time. This talk uses a newly developed tangential movement
theory to locate these boundaries in nearlysteady compressible flows.


TBA 15:10 Fri 30 Sep, 2011 :: Napier LG23 :: Prof Tony Roberts :: The University of Adelaide


Mathematical opportunities in molecular space 15:10 Fri 28 Oct, 2011 :: B.18 Ingkarni Wardli :: Dr Aaron Thornton :: CSIRO
The study of molecular motion, interaction and space at the nanoscale has become a powerful tool in the area of gas separation, storage and conversion for efficient energy solutions. Modeling in this field has typically involved highly iterative computational algorithms such as molecular dynamics, Monte Carlo and quantum mechanics. Mathematical formulae in the form of analytical solutions to this field offer a range of useful and insightful advantages including optimization, bifurcation analysis and standardization. Here we present a few case scenarios where mathematics has provided insight and opportunities for further investigation. 

Stability analysis of nonparallel unsteady flows via separation of variables 15:30 Fri 18 Nov, 2011 :: 7.15 Ingkarni Wardli :: Prof Georgy Burde :: BenGurion University
Media...The problem of variables separation in the linear stability
equations, which govern the disturbance behavior in viscous
incompressible fluid flows, is discussed.
Stability of some unsteady nonparallel threedimensional flows (exact
solutions of the NavierStokes equations)
is studied via separation of variables using a semianalytical, seminumerical approach.
In this approach, a solution with separated variables is defined in a new coordinate system which is sought together with the solution form. As the result, the linear stability problems are reduced to eigenvalue problems for ordinary differential equations which can be solved numerically.
In some specific cases, the eigenvalue
problems can be solved analytically. Those unique examples of exact
(explicit) solution of the nonparallel unsteady flow stability
problems provide a very useful test for methods used in the
hydrodynamic stability theory. Exact solutions of the stability problems for some stagnationtype flows are presented. 

Fluid flows in microstructured optical fibre fabrication 15:10 Fri 25 Nov, 2011 :: B.17 Ingkarni Wardli :: Mr Hayden Tronnolone :: University of Adelaide
Optical fibres are used extensively in modern telecommunications as they allow the transmission of information at high speeds. Microstructured optical fibres are a relatively new fibre design in which a waveguide for light is created by a series of air channels running along the length of the material. The flexibility of this design allows optical fibres to be created with adaptable (and previously unrealised) optical properties. However, the fluid flows that arise during fabrication can greatly distort the geometry, which can reduce the effectiveness of a fibre or render it useless. I will present an overview of the manufacturing process and highlight the difficulties. I will then focus on surfacetension driven deformation of the macroscopic version of the fibre extruded from a reservoir of molten glass, occurring during fabrication, which will be treated as a twodimensional Stokes flow problem. I will outline two different complexvariable numerical techniques for solving this problem along with comparisons of the results, both to other models and to experimental data.


Collision and instability in a rotating fluidfilled torus 15:10 Mon 12 Dec, 2011 :: Benham Lecture Theatre :: Dr Richard Clarke :: The University of Auckland
The simple experiment discussed in this talk, first conceived by Madden and
Mullin (JFM, 1994) as part of their investigations into the nonuniqueness
of decaying turbulent flow, consists of a fluidfilled torus which is
rotated in an horizontal plane. Turbulence within the contained flow is
triggered through a rapid change in its rotation rate. The flow
instabilities which transition the flow to this turbulent state, however,
are truly fascinating in their own right, and form the subject of this
presentation. Flow features observed in both UK and Aucklandbased
experiments will be highlighted, and explained through both boundarylayer
analysis and full DNS. In concluding we argue that this flow regime, with
its compact geometry and lack of cumbersome flow entry effects, presents an
ideal regime in which to study many prototype flow behaviours, very much in
the same spirit as TaylorCouette flow. 

Spinal Research at the University of Adelaide 11:10 Wed 14 Dec, 2011 :: B.17 Ingkarni Wardli :: Dr Robert Moore :: Adelaide Centre for Spinal Research


TBA 15:10 Mon 16 Jan, 2012 :: TBA :: Professsor Mike Foster :: Ohio State University


Spinal Research at the University of Adelaide 15:10 Fri 10 Feb, 2012 :: B.20 Ingkarni Wardli :: Dr Robert Moore :: Adelaide Centre for Spinal Research


Fluid mechanics: what's maths got to do with it? 13:10 Tue 20 Mar, 2012 :: 7.15 Ingkarni Wardli :: A/Prof Jim Denier :: School of Mathematical Sciences
Media...We've all heard about the grand challenges in mathematics. There was the Poincare Conjecture, which has now been resolved. There is the Riemann Hypothesis which many are seeking to prove. But one of the most intriguing is the so called "NavierStokes Equations" problem, intriguing because it not only involves some wickedly difficult mathematics but also involves questions about our deep understanding of nature as encountered in the flow of fluids. This talk will introduce the problem (without the wickedly difficult mathematics) and discuss some of the consequences of its resolution. 

Instability in standing waves in inhomogeneous nonlinear Schrodinger equations 13:10 Fri 30 Mar, 2012 :: B.17 Ingkarni Wardli :: Dr Robert Marangell :: The University of Sydney
Media...In this talk, I will describe a mechanism for determining
instability of standing wave solutions to a class of inhomogeneous nonlinear
Schrodinger (NLS) equations. The inhomogeneity in this case means that
the equations will spatially alternate between NLS and the socalled
GrossPitaevskii equation. Such equations are useful in 1D models of
BoseEinstein Condensates (BECs). The mechanism is inherently topological
and therefore robust, leading to its application to a number of different
soliton solutions, such as gap solitons, surface gap solitons, and dark
soliton among others. 

Spatialpoint data sets and the Polya distribution 15:10 Fri 27 Apr, 2012 :: B.21 Ingkarni Wardli :: Dr Benjamin Binder :: The University of Adelaide
Media...Spatialpoint data sets, generated from a wide range of
physical systems and mathematical
models, can be analyzed by counting the number of objects in equally
sized bins. We find that the bin
counts are related to the Polya distribution. New indexes are
developed which quantify whether or not a
spatial data set is at its most evenly distributed state. Using three
case studies (Lagrangian fluid particles in chaotic laminar
flows, cellular automata agents in discrete models, and biological
cells within colonies),
we calculate the indexes and predict the spatialstate of the system. 

Drawing of Viscous Threads with Temperaturedependent Viscosity 14:10 Fri 10 Aug, 2012 :: Engineering North N218 :: Dr Jonathan Wylie :: City University of Hong Kong
The drawing of viscous threads is important in a wide range of industrial
applications and is a primary manufacturing process in the optical fiber
and textile industries. Most of the materials used in these processes have
viscosities that vary extremely strongly with temperature.
We investigate the role played by viscous heating in the
drawing of viscous threads. Usually, the effects of viscous heating and
inertia are neglected because the parameters that characterize them are
typically very small. However, by performing a detailed theoretical
analysis we surprisingly show that even very small amounts of viscous
heating can lead to a runaway phenomena. On the other hand, inertia
prevents runaway, and the interplay between viscous heating and inertia
results in very complicated dynamics for the system.
Even more surprisingly, in the absence of viscous heating, we find that a
new type of instability can occur when a thread is heated by a radiative
heat source. By analyzing an asymptotic limit of the NavierStokes
equation we provide a theory that describes the nature of this instability
and explains the seemingly counterintuitive behavior.


Wave propagation in disordered media 15:10 Fri 31 Aug, 2012 :: B.21 Ingkarni Wardli :: Dr Luke Bennetts :: The University of Adelaide
Media...Problems involving wave propagation through systems composed of arrays of scattering sources embedded in some background medium will be considered. For example, in a fluids setting, the background medium is the open ocean surface and the scatterers are floating bodies, such as wave energy devices. Waves propagate in very different ways if the system is structured or disordered. If the disorder is random the problem is to determine the `effective' wave propagation properties by considering the ensemble average over all possible realisations of the system. I will talk about semianalytical (i.e. low numerical cost) approaches to determining the effective properties.


Electrokinetics of concentrated suspensions of spherical particles 15:10 Fri 28 Sep, 2012 :: B.21 Ingkarni Wardli :: Dr Bronwyn BradshawHajek :: University of South Australia
Electrokinetic techniques are used to gather specific information about concentrated dispersions such as electronic inks, mineral processing slurries, pharmaceutical products and biological fluids (e.g. blood). But, like most experimental techniques, intermediate quantities are measured, and consequently the method relies explicitly on theoretical modelling to extract the quantities of experimental interest. A selfconsistent cellmodel theory of electrokinetics can be used to determine the electrical conductivity of a dense suspension of spherical colloidal particles, and thereby determine the quantities of interest (such as the particle surface potential). The numerical predictions of this model compare well with published experimental results. High frequency asymptotic analysis of the cellmodel leads to some interesting conclusions. 

Complex analysis in low Reynolds number hydrodynamics 15:10 Fri 12 Oct, 2012 :: B.20 Ingkarni Wardli :: Prof Darren Crowdy :: Imperial College London
Media...It is a wellknown fact that the methods of complex analysis provide great advantage
in studying physical problems involving a harmonic field satisfying Laplace's equation.
One example is in ideal fluid mechanics (infinite Reynolds number)
where the absence of viscosity, and the
assumption of zero vorticity, mean that it is possible to introduce a socalled
complex potential  an analytic function from which all physical quantities of
interest can be inferred.
In the opposite limit of zero Reynolds number flows which are slow and viscous
and the governing fields are not harmonic
it is much less common to employ the methods of complex analysis
even though they continue to be relevant in certain circumstances.
This talk will give an overview of a variety of problems involving slow viscous Stokes
flows where complex analysis can be usefully employed to gain theoretical
insights. A number of example problems will be considered including
the locomotion of lowReynoldsnumber microorganisms and microrobots,
the friction properties of superhydrophobic surfaces in microfluidics and
problems of viscous sintering and the manufacture of microstructured optic fibres (MOFs). 

Thinfilm flow in helicallywound channels with small torsion 15:10 Fri 26 Oct, 2012 :: B.21 Ingkarni Wardli :: Dr Yvonne Stokes :: University of Adelaide
The study of flow in open helicallywound channels has application to many natural and industrial flows. We will consider laminar flow down helicallywound channels of rectangular cross section and with small torsion, in which the fluid depth is small. Assuming a steadystate flow that is independent of position along the axis of the channel, the flow solution may be determined in the twodimensional cross section of the channel. A thinfilm approximation yields explicit expressions for the fluid velocity in terms of the freesurface shape. The latter satisfies an interesting nonlinear ordinary differential equation that, for a channel of rectangular cross section, has an analytical solution. The predictions of the thinfilm model are shown to be in good agreement with much more computationally intensive solutions of the smallhelixtorsion NavierStokes equations.
This work has particular relevance to spiral particle separators used in the minerals processing industry. Early work on modelling of particleladen thinfilm flow in spiral channels will also be discussed. 

Thinfilm flow in helicallywound channels with small torsion 15:10 Fri 26 Oct, 2012 :: B.21 Ingkarni Wardli :: Dr Yvonne Stokes :: University of Adelaide
The study of flow in open helicallywound channels has application to many natural and industrial flows. We will consider laminar flow down helicallywound channels of rectangular cross section and with small torsion, in which the fluid depth is small. Assuming a steadystate flow that is independent of position along the axis of the channel, the flow solution may be determined in the twodimensional cross section of the channel. A thinfilm approximation yields explicit expressions for the fluid velocity in terms of the freesurface shape. The latter satisfies an interesting nonlinear ordinary differential equation that, for a channel of rectangular cross section, has an analytical solution. The predictions of the thinfilm model are shown to be in good agreement with much more computationally intensive solutions of the smallhelixtorsion NavierStokes equations.
This work has particular relevance to spiral particle separators used in the minerals processing industry. Early work on modelling of particleladen thinfilm flow in spiral channels will also be discussed. 

Group meeting 15:10 Fri 23 Aug, 2013 :: 5.58 (Ingkarni Wardli) :: Dr Barry Cox, Professor Tony Roberts & Stephen Wade :: University of Adelaide
Talk: Dr Barry Cox  'Conformation space of sevenmember rings'.
Work in progress discussion:
Professor Tony Roberts  Macroscale PDEs emerge from microscale dynamics with quantified
errors
Stephen Wade  Trapped waves in flow past a trench 

Group meeting 15:10 Fri 13 Sep, 2013 :: 5.58 (Ingkarni Wardli) :: Dr Sanjeeva Balasuriya and Dr Michael Chen :: University of Adelaide
Talks:
Nonautonomous control of invariant manifolds  Dr Sanjeeva Balasuriya ::
Interface problems in viscous flow  Dr Michael Chen 

Group meeting 15:10 Fri 25 Oct, 2013 :: 5.58 (Ingkarni Wardli) :: Dr Ben Binder and Mr David Wilke :: University of Adelaide
Dr Ben Binder :: 'An inverse approach for solutions to freesurface flow problems'
:: Abstract: Surface water waves are familiar to most people, for example, the wave
pattern generated at the stern of a ship. The boundary or interface
between the air and water is called the freesurface. When determining a
solution to a freesurface flow problem it is commonplace for the forcing
(eg. shape of ship or waterbed topography) that creates the surface waves
to be prescribed, with the freesurface coming as part of the solution.
Alternatively, one can choose to prescribe the shape of the freesurface
and find the forcing inversely. In this talk I will discuss my ongoing
work using an inverse approach to discover new types of solutions to
freesurface flow problems in two and three dimensions, and how the
predictions of the method might be verified with experiments. ::
Mr David Wilke:: 'A Computational Fluid Dynamic Study of Blood Flow Within the Coiled Umbilical Arteries'::
Abstract: The umbilical cord is the lifeline of the fetus throughout gestation. In a normal pregnancy it facilitates the supply of oxygen and nutrients from the placenta via a single vein, in addition to the return of deoxygenated blood from the developing embryo or fetus via two umbilical arteries. Despite the major role it plays in the growth of the fetus, pathologies of the umbilical cord are poorly understood. In particular, variations in the cord geometry, which typically forms a helical arrangement, have been correlated with adverse outcomes in pregnancy. Cords exhibiting either abnormally low or high levels of coiling have been associated with pathological results including growthrestriction and fetal demise. Despite this, the methodology currently employed by clinicians to characterise umbilical pathologies can misdiagnose cords and is prone to error. In this talk a computational model of blood flow within rigid threedimensional structures representative of the umbilical arteries will be presented. This study determined that the current characterization was unable to differentiate between cords which exhibited clinically distinguishable flow properties, including the cord pressure drop, which provides a measure of the loading on the fetal heart.


Developing Multiscale Methodologies for Computational Fluid Mechanics 12:10 Mon 11 Nov, 2013 :: B.19 Ingkarni Wardli :: Hammad Alotaibi :: University of Adelaide
Media...Recently the development of multiscale methods is one of the most fertile research areas in mathematics, physics, engineering and computer science. The need for multiscale modeling comes usually from the fact that the available macroscale models are not accurate enough, and the microscale models are not efficient enough. By combining both viewpoints, one hopes to arrive at a reasonable compromise between accuracy and efficiency.
In this seminar I will give an overview of the recent efforts on developing multiscale methods such as patch dynamics scheme which is used to address an important class of time dependent multiscale problems. 

A gentle introduction to bubble evolution in HeleShaw flows 15:10 Fri 22 Nov, 2013 :: 5.58 (Ingkarni Wardli) :: Dr Scott McCue :: QUT
A HeleShaw cell is easy to make and serves as a fun toy for an applied mathematician to play with. If we inject air into a HeleShaw cell that is otherwise filled with viscous fluid, we can observe a bubble of air growing in size. The process is highly unstable, and the bubble boundary expands in an uneven fashion, leading to striking fingering patterns (look up HeleShaw cell or SaffmanTaylor instability on YouTube). From a mathematical perspective, modelling these HeleShaw flows is interesting because the governing equations are sufficiently ``simple'' that a considerable amount of analytical progress is possible. Indeed, there is no other context in which (genuinely) twodimensional moving boundary problems are so tractable. More generally, HeleShaw flows are important as they serve as prototypes for more complicated (and important) physical processes such as crystal growth and diffusion limited aggregation. I will give an introduction to some of the main ideas and summarise some of my present research in this area.


Buoyancy driven exchange flows in the nearshore regions of lakes and reservoirs 15:10 Mon 2 Dec, 2013 :: 5.58 (Ingkarni Wardli) :: Professor John Patterson :: University of Sydney
Natural convection is the flow driven by differences in density, and is ubiquitous in nature and industry. It is the source of most environmental flows, and is the basis for almost all industrial heat exchange processes. It operates on both massive and micro scales. It is usually considered as a flow driven by temperature gradients, but could equally be from a gradient in any density determining property  salinity is one obvious example. It also depends on gravity; so magnetohydrodynamics becomes relevant as well. One particular interesting and environmentally relevant flow is the exchange flow in the nearshore regions of lakes and reservoirs. This occurs because of the effects of a decreasing depth approaching the shore resulting laterally unequal heat loss and heat gain during the diurnal cooling and heating cycle. This presentation will discuss some of the results obtained by the Natural Convection Group at Sydney University in analytical, numerical and experimental investigations of this mechanism, and the implications for lake water quality. 

The structuring role of chaotic stirring on pelagic ecosystems 11:10 Fri 28 Feb, 2014 :: B19 Ingkarni Wardli :: Dr Francesco d'Ovidio :: Universite Pierre et Marie Curie (Paris VI)
The open ocean upper layer is characterized by a complex transport dynamics occuring over different spatiotemporal scales. At the scale of 10100 km  which covers the so called mesoscale and part of the submesoscale  in situ and remote sensing observations detect strong variability in physical and biogeochemical fields like sea surface temperature, salinity, and chlorophyll concentration. The calculation of Lyapunov exponent and other nonlinear diagnostics applied to the surface currents have allowed to show that an important part of this tracer variability is due to chaotic stirring. Here I will extend this analysis to marine ecosystems. For primary producers, I will show that stable and unstable manifolds of hyperbolic points embedded in the surface velocity field are able to structure the phytoplanktonic community in fluid dynamical niches of dominant types, where competition can locally occur during bloom events. By using data from tagged whales, frigatebirds, and elephant seals, I will also show that chaotic stirring affects the behaviour of higher trophic levels. In perspective, these relations between transport structures and marine ecosystems can be the base for a biodiversity index constructued from satellite information, and therefore able to monitor key aspects of the marine biodiversity and its temporal variability at the global scale. 

Dynamical systems approach to fluidplasma turbulence 15:10 Fri 14 Mar, 2014 :: 5.58 Ingkarni Wardli :: Professor Abraham Chian
SunEarth system is a complex, electrodynamically coupled system dominated by multiscale interactions. The complex behavior of the space environment is indicative of a state driven far from equilibrium whereby instabilities, nonlinear waves, and turbulence play key roles in the system dynamics. First, we review the fundamental concepts of nonlinear dynamics in fluids and plasmas and discuss their relevance to the study of the SunEarth relation. Next, we show how Lagrangian coherent structures identify the transport barriers of plasma turbulence modeled by 3D solar convective dynamo. Finally, we show how Lagrangian coherent structures can be detected in the solar photospheric turbulence using satellite observations. 

Viscoelastic fluids: mathematical challenges in determining their relaxation spectra 15:10 Mon 17 Mar, 2014 :: 5.58 Ingkarni Wardli :: Professor Russell Davies :: Cardiff University
Determining the relaxation spectrum of a viscoelastic fluid is a crucial step before a linear or nonlinear constitutive model can be applied. Information about the relaxation spectrum is obtained from simple flow experiments such as creep or oscillatory shear. However, the determination process involves the solution of one or more highly illposed inverse problems. The availability of only discrete data, the presence of noise in the data, as well as incomplete data, collectively make the problem very hard to solve.
In this talk I will illustrate the mathematical challenges inherent in determining relaxation spectra, and also introduce the method of wavelet regularization which enables the representation of a continuous relaxation spectrum by a set of hyperbolic scaling functions.


CARRYING CAPACITY FOR FINFISH AQUACULTURE IN SPENCER GULF: RAPID ASSESSMENT USING HYDRODYNAMIC AND NEARFIELD, SEMI  ANALYTIC SOLUTIONS 15:10 Fri 11 Apr, 2014 :: 5.58 Ingkarni Wardli :: Associate Professor John Middleton :: SARDI Aquatic Sciences and University of Adelaide
Aquaculture farming involves daily feeding of finfish and a subsequent excretion of nutrients into Spencer Gulf. Typically, finfish farming is done in six or so 50m diameter cages and over 600m X 600m lease sites. To help regulate the industry, it is desired that the finfish feed rates and the associated nutrient flux into the ocean are determined such that the maximum nutrient concentration c does not exceed a prescribed value (say cP) for ecosystem health. The prescribed value cP is determined by guidelines from the E.P.A. The concept is known as carrying capacity since limiting the feed rates limits the biomass of the farmed finfish.
Here, we model the concentrations that arise from a constant input flux (F) of nutrients in a source region (the cage or lease) using the (depthaveraged) two dimensional, advection diffusion equation for constant and sinusoidal (tides) currents. Application of the divergence theorem to this equation results in a new scale estimate of the maximum flux F (and thus feed rate) that is given by
F= cP /T* (1)
where cP is the maximum allowed concentration and T* is a new time scale of âflushingâ that involves both advection and diffusion. The scale estimate (1) is then shown to compare favourably with mathematically exact solutions of the advection diffusion equation that are obtained using Greenâs functions and Fourier transforms. The maximum nutrient flux and associated feed rates are then estimated everywhere in Spencer Gulf through the development and validation of a hydrodynamic model. The model provides seasonal averages of the mean currents U and horizontal diffusivities KS that are needed to estimate T*. The diffusivities are estimated from a shear dispersal model of the tides which are very large in the gulf. The estimates have been provided to PIRSA Fisheries and Aquaculture to assist in the sustainable expansion of finfish aquaculture.


Group meeting 15:10 Fri 6 Jun, 2014 :: 5.58 Ingkarni Wardli :: Meng Cao and Trent Mattner :: University of Adelaide
Meng Cao:: Multiscale modelling couples patches of nonlinear wavelike simulations ::
Abstract:
The multiscale gaptooth scheme is built from given microscale simulations of complicated physical processes to empower macroscale simulations. By coupling small patches of simulations over unsimulated physical gaps, large savings in computational time are possible. So far the gaptooth scheme has been developed for dissipative systems, but wave systems are also of great interest. This article develops the gaptooth scheme to the case of nonlinear microscale simulations of wavelike systems. Classic macroscale interpolation provides a generic coupling between patches that achieves arbitrarily high order consistency between the multiscale scheme and the underlying microscale dynamics. Eigenanalysis indicates that the resultant gaptooth scheme empowers feasible computation of large scale simulations of wavelike dynamics with complicated underlying physics. As an pilot study, we implement numerical simulations of dambreaking waves by the gaptooth scheme. Comparison between a gaptooth simulation, a microscale simulation over the whole domain, and some published experimental data on dam breaking, demonstrates that the gaptooth scheme feasibly computes large scale wavelike dynamics with computational savings.
Trent Mattner :: Coupled atmospherefire simulations of the Canberra 2003 bushfires using WRFSfire :: Abstract:
The Canberra fires of January 18, 2003 are notorious for the extreme fire behaviour and fireatmospheretopography interactions that occurred, including leeslope fire channelling, pyrocumulonimbus development and tornado formation. In this talk, I will discuss coupled fireweather simulations of the Canberra fires using WRFSFire. In these simulations, a firebehaviour model is used to dynamically predict the evolution of the fire front according to local atmospheric and topographic conditions, as well as the associated heat and moisture fluxes to the atmosphere. It is found that the predicted fire front and heat flux is not too bad, bearing in mind the complexity of the problem and the severe modelling assumptions made. However, the predicted moisture flux is too low, which has some impact on atmospheric dynamics. 

Hydrodynamics and rheology of selfpropelled colloids 15:10 Fri 8 Aug, 2014 :: B17 Ingkarni Wardli :: Dr Sarthok Sircar :: University of Adelaide
The subcellular world has many components in common with soft condensed matter systems (polymers, colloids and liquid crystals). But it has novel properties, not present in traditional complex fluids, arising from a rich spectrum of nonequilibrium behavior: flocking, chemotaxis and bioconvection.
The talk is divided into two parts. In the first half, we will (get an idea on how to) derive a hydrodynamic model for selfpropelled particles of an arbitrary shape from first principles, in a sufficiently dilute suspension limit, moving in a 3dimensional space inside a viscous solvent. The model is then restricted to particles with ellipsoidal geometry to quantify the interplay of the longrange excluded volume and the shortrange selfpropulsion effects. The expression for the constitutive stresses, relating the kinetic theory with the momentum transport equations, are derived using a combination of the virtual work principle (for extra elastic stresses) and symmetry arguments (for active stresses).
The second half of the talk will highlight on my current numerical expertise. In particular we will exploit a specific class of spectral basis functions together with RK4 timestepping to determine the dynamical phases/structures as well as phasetransitions of these ellipsoidal clusters. We will also discuss on how to define the order (or orientation) of these clusters and understand the other rheological quantities.


Neural Development of the Visual System: a laminar approach 15:10 Fri 29 Aug, 2014 :: This talk will now be given as a School Colloquium :: Dr Andrew Oster :: Eastern Washington University
In this talk, we will introduce the architecture of the visual system in higher order primates and cats. Through activitydependent plasticity mechanisms, the left and right eye streams segregate in the cortex in a stripelike manner, resulting in a pattern called an ocular dominance map. We introduce a mathematical model to study how such a neural wiring pattern emerges. We go on to consider the joint development of the ocular dominance map with another feature of the visual system, the cytochrome oxidase blobs, which appear in the center of the ocular dominance stripes. Since cortex is in fact comprised of layers, we introduce a simple laminar model and perform a stability analysis of the wiring pattern. This intricate biological structure (ocular dominance stripes with 'blobs' periodically distributed in their centers) can be understood as occurring due to two Turing instabilities combined with the leadingorder dynamics of the system. 

Geometric singular perturbation theory and canard theory to study travelling waves in: 1) a model for tumor invasion; and 2) a model for wound healing angiogenesis. 15:10 Fri 17 Oct, 2014 :: EM 218 Engineering & Mathematics Building :: Dr Petrus (Peter) van Heijster :: QUT
In this talk, I will present results on the existence of smooth and shocklike travelling wave solutions for two advectionreactiondiffusion models.
The first model describes malignant tumour (i.e. skin cancer) invasion, while the second one is a model for wound healing angiogenesis.
Numerical solutions indicate that both smooth and shockfronted travelling wave solutions exist for these two models.
I will verify the existence of both type of these solutions using techniques from geometric singular perturbation theory and canard theory.
Moreover, I will provide numerical results on the stability of the waves and the actual observed wave speeds.
This is joint work with K. Harley, G. Pettet, R. Marangell and M. Wechselberger. 

Happiness and social information flow: Computational social science through data. 15:10 Fri 7 Nov, 2014 :: EM G06 (Engineering & Maths Bldg) :: Dr Lewis Mitchell :: University of Adelaide
The recent explosion in big data coming from online social networks has led to an increasing interest in bringing quantitative methods to bear on questions in social science. A recent highprofile example is the study of emotional contagion, which has led to significant challenges and controversy. This talk will focus on two issues related to emotional contagion, namely remotesensing of populationlevel wellbeing and the problem of information flow across a social network. We discuss some of the challenges in working with massive online data sets, and present a simple tool for measuring largescale happiness from such data. By combining over 10 million geolocated messages collected from Twitter with traditional census data we uncover geographies of happiness at the scale of states and cities, and discuss how these patterns may be related to traditional wellbeing measures and public health outcomes. Using tools from information theory we also study information flow between individuals and how this may relate to the concept of predictability for human behaviour. 

Happiness and social information flow: Computational social science through data. 15:10 Fri 7 Nov, 2014 :: EM G06 (Engineering & Maths Bldg) :: Dr Lewis Mitchell :: University of Adelaide
The recent explosion in big data coming from online social networks has led to an increasing interest in bringing quantitative methods to bear on questions in social science. A recent highprofile example is the study of emotional contagion, which has led to significant challenges and controversy. This talk will focus on two issues related to emotional contagion, namely remotesensing of populationlevel wellbeing and the problem of information flow across a social network. We discuss some of the challenges in working with massive online data sets, and present a simple tool for measuring largescale happiness from such data. By combining over 10 million geolocated messages collected from Twitter with traditional census data we uncover geographies of happiness at the scale of states and cities, and discuss how these patterns may be related to traditional wellbeing measures and public health outcomes. Using tools from information theory we also study information flow between individuals and how this may relate to the concept of predictability for human behaviour. 

Group Meeting 15:10 Fri 24 Apr, 2015 :: N218 Engineering North :: Dr Ben Binder :: University of Adelaide
Talk (Dr Ben Binder): How do we quantify the filamentous growth in a yeast colony?
Abstract: In this talk we will develop a systematic method to measure the spatial patterning of yeast colony morphology. The methods are applicable to other physical systems with circular spatial domains, for example, batch mixing fluid devices. A hybrid modelling approach of the yeast growth process will also be discussed.
After the seminar, Ben will start a group discussion by sharing some information and experiences on attracting honours/PhD students to the group. 

An EngineerMathematician Duality Approach to Finite Element Methods 12:10 Mon 18 May, 2015 :: Napier LG29 :: Jordan Belperio :: University of Adelaide
Media...The finite element method has been a prominently used numerical technique for engineers solving solid mechanics, electromagnetic and heat transfer problems for over 30 years. More recently the finite element method has been used to solve fluid mechanics problems, a field where finite difference methods are more commonly used.
In this talk, I will introduce the basic mathematics behind the finite element method, the similarity between the finite element method and finite difference method and comparing how engineers and mathematicians use finite element methods. I will then demonstrate two solutions to the wave equation using the finite element method. 

Group Meeting 15:10 Fri 29 May, 2015 :: EM 213 :: Dr Judy Bunder :: University of Adelaide
Talk : Patch dynamics for efficient exascale simulations
Abstract
Massive parallelisation has lead to a dramatic increase in available computational power.
However, data transfer speeds have failed to keep pace and are the major limiting factor in the development of exascale computing. New algorithms must be developed which minimise the transfer of data. Patch dynamics is a computational macroscale modelling scheme which provides a coarse macroscale solution of a problem defined on a fine microscale by dividing the domain into many nonoverlapping, coupled patches. Patch dynamics is readily adaptable to massive parallelisation as each processor core can evaluate the dynamics on one, or a few, patches. However, patch coupling conditions interpolate across the unevaluated parts of the domain between patches and require almost continuous data transfer. We propose a modified patch dynamics scheme which minimises data transfer by only reevaluating the patch coupling conditions at `mesoscale' time scales which are significantly larger than the microscale time of the microscale problem. We analyse and quantify the error arising from patch dynamics with mesoscale temporal coupling. 

Mathematical Modeling and Analysis of Active Suspensions 14:10 Mon 3 Aug, 2015 :: Napier 209 :: Professor Michael Shelley :: Courant Institute of Mathematical Sciences, New York University
Complex fluids that have a 'bioactive' microstructure, like
suspensions of swimming bacteria or assemblies of immersed biopolymers
and motorproteins, are important examples of socalled active matter.
These internally driven fluids can have strange mechanical properties,
and show persistent activitydriven flows and selforganization. I will
show how firstprinciples PDE models are derived through reciprocal
coupling of the 'active stresses' generated by collective microscopic
activity to the fluid's macroscopic flows. These PDEs have an
interesting analytic structures and dynamics that agree qualitatively
with experimental observations: they predict the transitions to flow
instability and persistent mixing observed in bacterial suspensions, and
for microtubule assemblies show the generation, propagation, and
annihilation of disclination defects. I'll discuss how these models
might be used to study yet more complex biophysical systems.


In vitro models of colorectal cancer: why and how? 15:10 Fri 7 Aug, 2015 :: B19 Ingkarni Wardli :: Dr Tamsin Lannagan :: Gastrointestinal Cancer Biology Group, University of Adelaide / SAHMRI
1 in 20 Australians will develop colorectal cancer (CRC) and it is the second most common cause of cancer death. Similar to many other cancer types, it is the metastases rather than the primary tumour that are lethal, and prognosis is defined by Ã¢ÂÂhow farÃ¢ÂÂ the tumour has spread at time of diagnosis. Modelling in vivo behavior through rapid and relatively inexpensive in vitro assays would help better target therapies as well as help develop new treatments. One such new in vitro tool is the culture of 3D organoids. Organoids are a biologically stable means of growing, storing and testing treatments against bowel cancer. To this end, we have just set up a human colorectal organoid bank across Australia. This consortium will help us to relate in vitro growth patterns to in vivo behaviour and ultimately in the selection of patients for personalized therapies. Organoid growth, however, is complex. There appears to be variable growth rates and growth patterns. Together with members of the ECMS we recently gained funding to better quantify and model spatial structures in these colorectal organoids. This partnership will aim to directly apply the expertise within the ECMS to patient care. 

Nearmotiontrapping in rings of cylinders (and why this is the worst possible wave energy device) 15:10 Fri 30 Oct, 2015 :: Ingkarni Wardli B21 :: Dr Hugh Wolgamot :: University of Western Australia
Motion trapping structures can oscillate indefinitely when floating in an ideal fluid. This talk discusses a simple structure which is predicted to have very close to perfect trapping behaviour, where the structure has been investigated numerically and (for the first time) experimentally. While endless oscillations were evidently not observed experimentally, remarkable differences between 'tuned' and 'detuned' structures were still apparent, and simple theory is sufficient to explain much of the behaviour. A connection with wave energy will be briefly explored, though the link is not fruitful! 

Group meeting 15:10 Fri 20 Nov, 2015 :: Ingkarni Wardli B17 :: Mr Jack Keeler :: University of East Anglia / University of Adelaide
Title: Stability of freesurface flow over topography
Abstract: The forced KdV equation is used as a model to analyse the wave behaviour on the free surface in response to prescribed topographic forcing. The research involves computing steady solutions using numeric and asymptotic techniques and then analysing the stability of these steady solutions in timedependent calculations. Stability is analysed by computing the eigenvalue spectra of the linearised fKdV operator and by exploiting the Hamiltonian structure of the fKdV. Future work includes analysing the solution space for a corrugated topography and investigating the 3 dimensional problem using the KP equation.
+ Any items for group discussion 

Group meeting 15:10 Fri 20 Nov, 2015 :: Ingkarni Wardli B17 :: Mr Jack Keeler :: University of East Anglia / University of Adelaide
Title: Stability of freesurface flow over topography
Abstract: The forced KdV equation is used as a model to analyse the wave behaviour on the free surface in response to prescribed topographic forcing. The research involves computing steady solutions using numeric and asymptotic techniques and then analysing the stability of these steady solutions in timedependent calculations. Stability is analysed by computing the eigenvalue spectra of the linearised fKdV operator and by exploiting the Hamiltonian structure of the fKdV. Future work includes analysing the solution space for a corrugated topography and investigating the 3 dimensional problem using the KP equation.
+ Any items for group discussion 

Group meeting 15:10 Fri 11 Mar, 2016 :: TBA
TBA
+ Any items for group discussion 

Hot tube tau machine 15:10 Fri 15 Apr, 2016 :: B17 Ingkarni Wardli :: Dr Hayden Tronnolone :: University of Adelaide
Abstract: Microstructured optical fibres may be fabricated by first extruding molten material from a die to produce a macroscopic version of the final design, call a preform, and then stretching this to produce a fibre. In this talk I will demonstrate how to couple an existing model of the fluid flow during the extrusion stage to a basic model of the fluid temperature and present some preliminary conclusions. This work is still in progress and is being carried out in collaboration with Yvonne Stokes, Michael Chen and Jonathan Wylie.
(+ Any items for group discussion) 

Behavioural Microsimulation Approach to Social Policy and Behavioural Economics 15:10 Fri 20 May, 2016 :: S112 Engineering South :: Dr Drew Mellor :: Ernst & Young
SIMULAIT is a general purpose, behavioural microsimulation system designed to predict behavioural trends in human populations. This type of predictive capability grew out of original research initially conducted in conjunction with the Defence Science and Technology Group (DSTO) in South Australia, and has been fully commercialised and is in current use by a global customer base. To our customers, the principal value of the system lies in its ability to predict likely outcomes to scenarios that challenge conventional approaches based on extrapolation or generalisation. These types of scenarios include: the impact of disruptive technologies, such as the impact of widespread adoption of autonomous vehicles for transportation or batteries for household energy storage; and the impact of effecting policy elements or interventions, such as the impact of imposing water usage restrictions.
SIMULAIT employs a multidisciplinary methodology, drawing from agentbased modelling, behavioural science and psychology, microeconomics, artificial intelligence, simulation, game theory, engineering, mathematics and statistics. In this seminar, we start with a highlevel view of the system followed by a look under the hood to see how the various elements come together to answer questions about behavioural trends. The talk will conclude with a case study of a recent application of SIMULAIT to a significant policy problem  how to address the deficiency of STEM skilled teachers in the Victorian teaching workforce. 

Multiscale modeling in biofluids and particle aggregation 15:10 Fri 17 Jun, 2016 :: B17 Ingkarni Wardli :: Dr Sarthok Sircar :: University of Adelaide
In today's seminar I will give 2 examples in mathematical biology which describes the multiscale organization at 2 levels: the meso/micro level and the continuum/macro level. I will then detail suitable tools in statistical mechanics to link these different scales.
The first problem arises in mathematical physiology: swellingdeswelling mechanism of mucus, an ionic gel. Mucus is packaged inside cells at high concentration (volume fraction) and when released into the extracellular environment, it expands in volume by two orders of magnitude in a matter of seconds. This rapid expansion is due to the rapid exchange of calcium and sodium that changes the crosslinked structure of the mucus polymers, thereby causing it to swell. Modeling this problem involves a twophase, polymer/solvent mixture theory (in the continuum level description), together with the chemistry of the polymer, its nearest neighbor interaction and its binding with the dissolved ionic species (in the microscale description). The problem is posed as a freeboundary problem, with the boundary conditions derived from a combination of variational principle and perturbation analysis. The dynamics of neutral gels and the equilibriumstates of the ionic gels are analyzed.
In the second example, we numerically study the adhesion fragmentation dynamics of rigid, round particles clusters subject to a homogeneous shear flow. In the macro level we describe the dynamics of the number density of these cluster. The description in the microscale includes (a) binding/unbinding of the bonds attached on the particle surface, (b) bond torsion, (c) surface potential due to ionic medium, and (d) flow hydrodynamics due to shear flow. 

Approaches to modelling cells and remodelling biological tissues 14:10 Wed 10 Aug, 2016 :: Ingkarni Wardli 5.57 :: Professor Helen Byrne :: University of Oxford
Biological tissues are complex structures, whose evolution is characterised by multiple biophysical processes that act across diverse space and time scales. For example, during normal wound healing, fibroblast cells located around the wound margin exert contractile forces to close the wound while those located in the surrounding tissue synthesise new tissue in response to local growth factors and mechanical stress created by wound contraction. In this talk I will illustrate how mathematical modelling can provide insight into such complex processes, taking my inspiration from recent studies of cell migration, vasculogenesis and wound healing. 

Some results on the stability of flat Stokes layers 15:10 Fri 14 Oct, 2016 :: Ingkarni Wardli 5.57 :: Professor Andrew Bassom :: University of Tasmania
The flat Stokes layer is one of the relatively few exact solutions of the incompressible NavierStokes equations. For that reason the temporal stability of the layer has attracted considerable interest over the years. Fortunately, not only is the issue one solely of academic curiosity, but some kind of Stokes layer is likely to be set up at the boundaries of any physical timeperiodic flow making its stability of practical interest as well. In this talk I shall review progress made in the understanding of the linear stability properties of the flow. In particular I will discuss the fact that theoretical predictions of critical conditions are wildly different from those observed in the laboratory. 

Fault tolerant computation of hyperbolic PDEs with the sparse grid combination technique 15:10 Fri 28 Oct, 2016 :: Ingkarni Wardli 5.57 :: Dr Brendan Harding :: University of Adelaide
Computing solutions to high dimensional problems is challenging because of the curse of dimensionality. The sparse grid combination technique allows one to significantly reduce the cost of computing solutions such that they become manageable on current supercomputers. However, as these supercomputers increase in size the rate of failure also increases. This poses a challenge for our computations. In this talk we look at the problem of computing solutions to hyperbolic partial differential equations with the combination technique in an environment where faults occur. A fault tolerant generalisation of the combination technique will be presented along with results that demonstrate its effectiveness. 

Segregation of particles in incompressible flows due to streamline topology and particleboundary interaction 15:10 Fri 2 Dec, 2016 :: Ingkarni Wardli 5.57 :: Professor Hendrik C. Kuhlmann :: Institute of Fluid Mechanics and Heat Transfer, TU Wien, Vienna, Austria
Media...The incompressible flow in a number of classical benchmark problems (e.g. liddriven cavity, liquid bridge) undergoes an instability from a twodimensional steady to a periodic threedimensional flow, which is steady or in form of a traveling wave, if the Reynolds number is increased. In the supercritical regime chaotic as well as regular (quasiperiodic) streamlines can coexist for a range of Reynolds numbers. The spatial structures of the regular regions in threedimensional NavierStokes flows has received relatively little attention, partly because of the high numerical effort required for resolving these structures. Particles whose density does not differ much from that of the liquid approximately follow the chaotic or regular streamlines in the bulk. Near the boundaries, however, their trajectories strongly deviate from the streamlines, in particular if the boundary (wall or free surface) is moving tangentially. As a result of this particleboundary interaction particles can rapidly segregate and be attracted to periodic or quasiperiodic orbits, yielding particle accumulation structures (PAS). The mechanism of PAS will be explained and results from experiments and numerical modelling will be presented to demonstrate the generic character of the phenomenon. 

Lagrangian transport in deterministic flows: from theory to experiment 16:10 Tue 16 May, 2017 :: Engineering North N132 :: Dr Michel Speetjens :: Eindhoven University of Technology
Transport of scalar quantities (e.g. chemical species, nutrients, heat) in deterministic flows is key to a wide range of phenomena and processes in industry and Nature. This encompasses length scales ranging from microns to hundreds of kilometres, and includes systems as diverse as viscous flows in the processing industry, microfluidic flows in labsonachip and porous media, largescale geophysical and environmental flows, physiological and biological flows and even continuum descriptions of granular flows.
Essential to the net transport of a scalar quantity is its advection by the fluid motion. The Lagrangian perspective (arguably) is the most natural way to investigate advection and leans on the fact that fluid trajectories are organized into coherent structures that geometrically determine the advective transport properties. Lagrangian transport is typically investigated via theoretical and computational studies and often concerns idealized flow situations that are difficult (or even impossible) to create in laboratory experiments. However, bridging the gap from theoretical and computational results to realistic flows is essential for their physical meaningfulness and practical relevance. This presentation highlights a number of fundamental Lagrangian transport phenomena and properties in both twodimensional and threedimensional flows and demonstrates their physical validity by way of representative and experimentally realizable flows. 

Serotonin Movement Through the Human Colonic Mucosa 15:10 Fri 19 May, 2017 :: Ingkarni Wardli 5.57 :: Helen Dockrell :: Flinders University / Flinders Medical Centre
The control of gut motility remains poorly defined and this makes it difficult to treat disorders associated with dysmotility in patient populations. Intestinal serotonin can elicit and modulate colonic motor patterns and is released in response to a variety of stimuli including nutrient ingestion and pressure change. I will describe a computational model of intestinal tissue and the predicted movement of serotonin through this tissue by advection and diffusion following pressuredependent release. I have developed this model as a PhD candidate under the supervision of Associate Professor Phil Dinning, Professor Damien Keating and Dr Lukasz Wilendt. 

Stokes' Phenomenon in Translating Bubbles 15:10 Fri 2 Jun, 2017 :: Ingkarni Wardli 5.57 :: Dr Chris Lustri :: Macquarie University
This study of translating air bubbles in a HeleShaw cell containing viscous fluid reveals the critical role played by surface tension in these systems. The standard zerosurfacetension model of HeleShaw flow predicts that a continuum of bubble solutions exists for arbitrary flow translation velocity. The inclusion of small surface tension, however, eliminates this continuum of solutions, instead producing a discrete, countably infinite family of solutions, each with distinct translation speeds. We are interested in determining this discrete family of solutions, and understanding why only these solutions are permitted.
Studying this problem in the asymptotic limit of small surface tension does not seem to give any particular reason why only these solutions should be selected. It is only by using exponential asymptotic methods to study the Stokesâ structure hidden in the problem that we are able to obtain a complete picture of the bubble behaviour, and hence understand the selection mechanism that only permits certain solutions to exist.
In the first half of my talk, I will explain the powerful ideas that underpin exponential asymptotic techniques, such as analytic continuation and optimal truncation. I will show how they are able to capture behaviour known as Stokes' Phenomenon, which is typically invisible to classical asymptotic series methods. In the second half of the talk, I will introduce the problem of a translating air bubble in a HeleShaw cell, and show that the behaviour can be fully understood by examining the Stokes' structure concealed within the problem. Finally, I will briefly showcase other important physical applications of exponential asymptotic methods, including submarine waves and particle chains. 

Aggregation patterns from local and nonlocal interactions 15:10 Fri 30 Jun, 2017 :: Ingkarni Wardli 5.57 :: Dr Emily HackettJones :: Centre for Cancer Biology, University of South Australia
Biological aggregations are ubiquitous in nature and may arise from a number of different mechanisms  both local and nonlocal. I will discuss two
such mechanisms with particular application to the enteric nervous system; the nervous system in the gut responsible for peristalsis. Aggregates of neurons with a particular form are necessary for normal gut development. Our work suggests possible explanations for observations in normal and abnormal gut development. 

How oligomerisation impacts steady state gradient in a morphogenreceptor system 15:10 Fri 20 Oct, 2017 :: Ingkarni Wardli 5.57 :: Mr Phillip Brown :: University of Adelaide
In developmental biology an important process is cell fate determination, where cells start to differentiate their form and function. This is an element of the broader concept of morphogenesis. It has long been held that cell differentiation can occur by a chemical signal providing positional information to 'undecided' cells. This chemical produces a gradient of concentration that indicates to a cell what path it should develop along. More recently it has been shown that in a particular system of this type, the chemical (protein) does not exist purely as individual molecules, but can exist in multiprotein complexes known as oligomers.
Mathematical modelling has been performed on systems of oligomers to determine if this concept can produce useful gradients of concentration. However, there are wide range of possibilities when it comes to how oligomer systems can be modelled and most of them have not been explored.
In this talk I will introduce a new monomer system and analyse it, before extending this model to include oligomers. A number of oligomer models are proposed based on the assumption that proteins are only produced in their oligomer form and can only break apart once they have left the producing cell. It will be shown that when oligomers are present under these conditions, but only monomers are permitted to bind with receptors, then the system can produce robust, biologically useful gradients for a significantly larger range of model parameters (for instance, degradation, production and binding rates) compared to the monomer system. We will also show that when oligomers are permitted to bind with receptors there is negligible difference compared to the monomer system. 

TBA 15:10 Fri 16 Feb, 2018 :: Ingkarni Wardli 5.57 :: Dr Guillermo Gomez :: Centre for Cancer Research, University of South Australia


A multiscale approximation of a CahnLarche system with phase separation on the microscale 15:10 Thu 22 Feb, 2018 :: Ingkarni Wardli 5.57 :: Ms Lisa Reischmann :: University of Augsberg
We consider the process of phase separation of a binary system under the influence of mechanical deformation and we derive a mathematical multiscale model, which describes the evolving microstructure taking into account the elastic properties of the involved materials.
Motivated by phaseseparation processes observed in lipid monolayers in filmbalance experiments, the starting point of the model is the CahnHilliard equation coupled with the equations of linear elasticity, the socalled CahnLarche system.
Owing to the fact that the mechanical deformation takes place on a macrosopic scale whereas the phase separation happens on a microscopic level, a multiscale approach is imperative.
We assume the pattern of the evolving microstructure to have an intrinsic length scale associated with it, which, after nondimensionalisation, leads to a scaled model involving a small parameter epsilon>0, which is suitable for periodichomogenisation techniques.
For the full nonlinear problem the socalled homogenised problem is then obtained by letting epsilon tend to zero using the method of asymptotic expansion.
Furthermore, we present a linearised CahnLarche system and use the method of twoscale convergence to obtain the associated limit problem, which turns out to have the same structure as in the nonlinear case, in a mathematically rigorous way. Properties of the limit model will be discussed. 

How long does it take to get there? 11:10 Fri 19 Oct, 2018 :: Engineering North N132 :: Professor Herbert Huppert :: University of Cambridge
In many situations involving nonlinear partial differential equations, requiring much numerical calculation because there is no analytic solution, it is possible to find a similarity solution to the resulting (still nonlinear) ordinary differential equation; sometimes even analytically, but it is generally independent of the initial conditions. The similarity solution is said to approach the real solution for t >> tau, say. But what is tau? How does it depend on the parameters of the problem and the initial conditions? Answers will be presented for a variety of problems and the audience will be asked to suggest others if they know of them.


Some advances in the formulation of analytical methods for linear and nonlinear dynamics 15:10 Tue 20 Nov, 2018 :: EMG07 :: Dr Vladislav Sorokin :: University of Auckland
In the modern engineering, it is often necessary to solve problems involving strong parametric excitation and (or) strong nonlinearity. Dynamics of micro and nanoscale electromechanical systems, wave propagation in structures made of corrugated composite materials are just examples of those. Numerical methods, although able to predict systems behavior for specific sets of parameters, fail to provide an insight into underlying physics. On the other hand, conventional analytical methods impose severe restrictions on the problem parameters space and (or) on types of the solutions.
Thus, the quest for advanced tools to deal with linear and nonlinear structural dynamics still continues, and the lecture is concerned with an advanced formulation of an analytical method. The principal novelty aspect is that the presence of a small parameter in governing equations is not requested, so that dynamic problems involving strong parametric excitation and (or) strong nonlinearity can be considered. Another advantage of the method is that it is free from conventional restrictions on the excitation frequency spectrum and applicable for problems involving combined multiple parametric and (or) direct excitations with incommensurate frequencies, essential for some applications.
A use of the method will be illustrated in several examples, including analysis of the effects of corrugation shapes on dispersion relation and frequency bandgaps of structures and dynamics of nonlinear parametric amplifiers. 

The role of microenvironment in regulation of cell infiltration and bortezomibOV therapy in glioblastoma 15:10 Fri 11 Jan, 2019 :: IW 5.57 :: Professor Yangjin Kim :: Konkuk University, South Korea
Tumor microenvironment (TME) plays a critical role in regulation of tumor cell invasion in glioblastoma. Many microenvironmental factors such as extracllular matrix, microglia and astrocytes can either block or enhance this critical infiltration step in brain [4]. Oncolytic viruses such as herpes simplex virus1 (oHSV) are genetically modified to target and kill cancer cells while not harming healthy normal cells and are currently under multiple clinical trials for safety and efficacy [1]. Bortezomib is a peptidebased proteasome inhibitor and is an FDAapproved drug for myeloma and mantle cell lymphoma. Yoo et al (2) have previously demonstrated that bortezomibinduced unfolded protein response (UPR) in many tumor cell lines (glioma, ovarian, and head and neck) upregulated expression of heat shock protein 90 (HSP90), which then enhanced viral replication through promotion of nuclear localization of the viral polymerase in vitro. This led to synergistic tumor cell killing in vitro, and a combination treatment of mice with oHSV and bortezomib showed improved antitumor efficacy in vivo [2]. This combination therapy also increased the surface expression levels of NK cell activating markers and enhanced proinflammatory cytokine secretion. These findings demonstrated that the synergistic interaction between oHSV and bortezomib, a clinically relevant proteasome inhibitor, augments the cancer cell killing and promotes overall therapeutic efficacy. We investigated the role of NK cells in combination therapy with oncolytic virus (OV) and bortezomib. NK cells display rapid and potent immunity to metastasis and hematological cancers, and they overcome immunosuppressive effects of tumor microenvironment. We developed a mathematical model, a system of PDEs, in order to address the question of how the density of NK cells affects the growth of the tumor [3]. We found that the antitumor efficacy increases when the endogenous NKs are depleted, and also when exogenous NK cells are injected into the tumor. We also show that the TME plays a significant role in antitumor efficacy in OV combination therapy, and illustrate the effect of different spatial patterns of OV injection [5]. The results illustrate a possible phenotypic switch within tumor populations in a given microenvironment, and suggest new antiinvasion therapies. These predictions were validated by our in vivo and in vitro experiments.
References
1] Â Kanai R, â¦ Rabkin SD, âOncolytic herpes simplex virus vectors and chemotherapy: are combinatorial strategies more effective for cancer?â, Future Oncology, 6(4), 619â634, 2010. â¨
[2] Â Yoo J, et al., âBortezomibinduced unfolded protein response increases oncolytic hsv1 replication resulting in synergistic antitumor effectâ, Clin Cancer Res , Vol. 20(14), 2014, pp. 37873798. â¨
[3] Â Yangjin Kim,..Balveen Kaur and Avner Friedman, âComplex role of NK cells in regulation of oncolytic virusbortezomib therapyâ, PNAS, 115 (19), pp. 49274932, 2018. â¨
[4] Yangjin Kim, ..Sean Lawler, and Mark Chaplain, âRole of extracellular matrix and microenvironment in regulation of tumor growth and LARmediated invasion in glioblastomaâ, PLoS One, 13(10):e0204865, 2018. â¨
[5] Yangjin Kim, â¦, Hans G. Othmer, âSynergistic effects of bortezomibOV therapy and antiinvasiveâ¨strategies in glioblastoma: A mathematical modelâ, Special issue, submitted, 2018. 
Publications matching "+Fluid +mechanics"Publications 

On satisfying the radiation condition in freesurface flows Binder, Benjamin; VandenBroeck, J; Dias, F, Journal of Fluid Mechanics 624 (179–189) 2009  The effect of disturbances on the flows under a sluice gate and past an inclined plate Binder, Benjamin; VandenBroeck, J, Journal of Fluid Mechanics 576 (475–490) 2007  An accurate and comprehensive model of thin fluid flows with inertia on curved substrates Roberts, Anthony John; Li, Z, Journal of Fluid Mechanics 553 (33–73) 2006  On the growth (and suppression) of very shortscale disturbances in mixed forcedfree convection boundary layers Denier, James; Duck, P; Li, JM, Journal of Fluid Mechanics 526 (147–170) 2005  The drag on a microcantilever oscillating near a wall Clarke, Richard; Cox, Stephen; Williams, P; Jensen, O, Journal of Fluid Mechanics 545 (397–426) 2005  Asymptotic matching constraints for a boundarylayer flow of a powerlaw fluid Denier, James; Hewitt, R, Journal of Fluid Mechanics 518 (261–279) 2004  The role of inertia in extensional fall of a viscous drop Stokes, Yvonne; Tuck, Ernest, Journal of Fluid Mechanics 498 (205–225) 2004  Lowdimensional modelling of dynamical systems applied to some dissipative fluid mechanics Roberts, Anthony John, chapter in Nonlinear dynamics: from lasers to butterflies (World Scientific Publishing) 257–313, 2003  Vortical flow. Part 2. Flow past a sphere in a constantdiameter pipe Mattner, Trent; Joubert, P; Chong, Min, Journal of Fluid Mechanics 481 (1–36) 2003  14th Australasian Fluid Mechanics Conference  Preface Dally, Bassam; Kelso, Richard; Nathan, Graham; Denier, James, Experimental Thermal and Fluid Science 27 (505–506) 2003  A lubrication model of coating flows over a curved substrate in space Roy, R; Roberts, Anthony John; Simpson, M, Journal of Fluid Mechanics 454 (235–261) 2002  Vortical flow. Part 1. Flow through a constantdiameter pipe Mattner, Trent; Joubert, P; Chong, Min, Journal of Fluid Mechanics 463 (259–291) 2002  The supercritical bore produced by a highspeed ship in a channel Gourlay, Timothy, Journal of Fluid Mechanics 434 (399–409) 2001  Extensional fall of a very viscous fluid drop Stokes, Yvonne; Tuck, Ernest; Schwartz, L, Quarterly Journal of Mechanics and Applied Mathematics 53 (565–582) 2000 
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